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Quest Reward Items in Borderlands 2 can be farmed on PC by Read-Only farming.

How to Read-Only farm:

1. Go to the location where you hand in the quest.
2. Save the game by toggling your Badass Rank on/off.
3. Then go into the file explorer on your computer. Go to the file path:
   C:\Users\NAME\Documents\My Games\Borderlands 2\WillowGame\SaveData
4. Go to your most recent Save File (.sav) and:
   right-click → properties
5. Under General tick the Read-only box.
6. Back in-game and hand in the quest.
7. Exit to the main menu, then back into the game.
8. Now you will be able to hand in the quest again.

Tip: Store the items in Claptrap's Secret Stash.
This way you can get the quest reward items multiple times since they are saved on a different SaveFile.

In Borderlands 3 Quest Reward Items are rewarded after or during a quest. After the quest is completed there are 2 ways to farm base game items:

• Eridian Fabricator:
  On the Legendary firing mode, the Eridian Fabricator occasionally drops quest reward items.
• Crazy Earl's Veteran Rewards machine in Sanctuary has one Quest Rewards as the Item of the day.